Architecture and Performance Tuning for Healthcare Data Exchange
Keywords:
HL7 Fast Healthcare Interoperability Resources (FHIR), Real-Time Healthcare Data Exchange, Event-Driven Architecture, FHIR RESTful Services, Healthcare Systems Integration, Low-Latency Clinical Data Processing, Interoperability Standards in Healthcare, Event-Based Integration Patterns, Cloud-Enabled Healthcare Platforms, Secure Health Information Exchange, Protocol Translation Frameworks, Healthcare API Design, Life-Critical Clinical Systems, Publish–Subscribe Mechanisms, Open-Source Healthcare Integration Frameworks, Scalable Health IT Architectures.Abstract
The use of Health Level 7's Fast Healthcare Interoperability Resources (FHIR) for facilitating real-time data exchange among healthcare systems in life-critical scenarios enables patients to receive timely and appropriate treatment whenever and wherever they need it. FHIR provides models, rules, and interfaces for data exchange between computerized applications operating in the healthcare domain. Being a web-based standard, it can be easily deployed using an event-based architecture. Furthermore, it allows for online communications and moves away from standard file batch processes. The eventing mechanism facilitates the push of data from an event publisher to interested subscribers and notifies them of updates for resources of interest.
The increasing diversity and complexity of healthcare information systems, along with the demand for timely integration of data across these systems, point toward the need for a real-time event-based integration approach using FHIR REST services. Open-source frameworks have been developed for achieving the required integration. However, architectural decisions in designing such frameworks have a significant impact on their ability to support data exchange with low latency. The selection of an appropriate integration architecture is also crucial for meeting requirements such as interaction with external enterprises, protocol translation, security, and compliance with cloud deployment models. Therefore, several architecture patterns commonly considered and deployed for event-based integration using FHIR are discussed. Each architecture pattern is detailed, along with its strengths and weaknesses for supporting real-time data exchange.
References
1. Ayaz, M., Pasha, M. F., Alzahrani, M. Y., Budiarto, R., & Stiawan, D. (2021). The Fast Health Interoperability Resources (FHIR) standard: Systematic literature review of implementations, applications, challenges and opportunities. Journal of Medical Internet Research, 9(7), e21929.
2. Mukhiya, S. K., & Lamo, Y. (2021). An HL7 FHIR and GraphQL approach for interoperability between heterogeneous electronic health record systems. Health Informatics Journal, 27(3), 14604582211043920.
3. Mangalampalli, B. M. Generative AI Applications In Healthcare Data Mart Design And Optimization.
4. Wesley, D. B., Blumenthal, J., Shah, S., Littlejohn, R. A., Pruitt, Z., Dixit, R., Hsiao, C.-J., Dymek, C., & Ratwani, R. M. (2021). A novel application of SMART on FHIR architecture for interoperable and scalable integration of patient-reported outcome data with electronic health records. Journal of the American Medical Informatics Association, 28(10), 2220–2225.
5. Cheng, A. C., Duda, S. N., Taylor, R., Delacqua, F., et al. (2021). REDCap on FHIR: Clinical data interoperability services. Journal of Biomedical Informatics, 121, 103871.
6. Inala, R. Designing Scalable Technology Architectures for Customer Data in Group Insurance and Investment Platforms.
7. Seong, D., Jung, S., Bae, S., Chung, J., Son, D.-S., & Yi, B.-K. (2021). Fast Healthcare Interoperability Resources (FHIR)–based quality information exchange for clinical next-generation sequencing genomic testing: Implementation study. Journal of Medical Internet Research, 23(4), e26261.
8. De, A., Huang, M., Feng, T., Yue, X., & Yao, L. (2021). Analyzing patient secure messages using a Fast Health Care Interoperability Resources (FHIR)–based data model: Development and topic modeling study. Journal of Medical Internet Research, 23(7), e26770.
9. Inala, R. (2023). AI-powered investment decision support systems: Building smart data products with embedded governance controls. Journal for ReAttach Therapy and Developmental Diversities, 6(10), 2251-2266.
10. Lenert, L. A., Ilatovskiy, A. V., Agnew, J., Rudisill, P., Jacobs, J., Weatherston, D., & Deans, K. R., Jr. (2021). Automated production of research data marts from a canonical Fast Healthcare Interoperability Resource data repository: Applications to COVID-19 research. Journal of the American Medical Informatics Association, 28(8), 1605–1611.
11. Strasberg, H. R., Rhodes, B., Del Fiol, G., Jenders, R. A., Haug, P. J., & Kawamoto, K. (2021). Contemporary clinical decision support standards using Health Level Seven International Fast Healthcare Interoperability Resources. Journal of the American Medical Informatics Association, 28(8), 1796–1806.
12. Amistapuram, K. (2023). Privacy-Preserving Machine Learning Models for Sensitive Customer Data in Insurance Systems. Educational Administration: Theory and Practice, 29(4), 5950-5958.
13. Hettinger, A. Z., Melnick, E. R., & Ratwani, R. M. (2021). Advancing electronic health record vendor usability maturity: Progress and next steps. Journal of the American Medical Informatics Association, 28(5), 1029–1031.
14. Gulden, C., Blasini, R., Nassirian, A., Stein, A., Altun, F. B., Kirchner, M., Prokosch, H.-U., & Boeker, M. (2021). Prototypical clinical trial registry based on Fast Healthcare Interoperability Resources (FHIR): Design and implementation study. JMIR Medical Informatics, 9(1), e20470.
15. Vorisek, C. N., Lehne, M., Klopfenstein, S. A. I., Mayer, P. J., Bartschke, A., Haese, T., & Thun, S. (2022). Fast Healthcare Interoperability Resources (FHIR) for interoperability in health research: Systematic review. JMIR Medical Informatics, 10(7), e35724.
16. KollIntegration. South Eastern European Journal of Public Health, 248–260.
17. Cheng, K. Y., Pazmino, S., & Schreiweis, B. (2022). ETL processes for integrating healthcare data—Tools and architecture patterns. Studies in Health Technology and Informatics, 294, 974–978.
18. Sarkar, I. N. (2022). Transforming health data to actionable information: Recent progress and future opportunities in health information exchange. Yearbook of Medical Informatics, 31(1), 203–214.
19. Janakiraman, R., Park, E., Demirezen, E. M., & Kumar, S. (2022). The effects of health information exchange access on healthcare quality and efficiency: An empirical investigation. Management Science, 69(2), 791–811.
20. Yandamuri, U. S. (2023). An Intelligent Analytics Framework Combining Big Data and Machine Learning for Business Forecasting. Zenodo.
21. Chatterjee, A., Pahari, N., & Prinz, A. (2022). HL7 FHIR with SNOMED-CT to achieve semantic and structural interoperability in personal health data: A proof-of-concept study. Sensors, 22(10), 3756.
22. Gruendner, J., Deppenwiese, N., Folz, M., Köhler, T., Kroll, B., Prokosch, H.-U., Rosenau, L., Rühle, M., Scheidl, M. A., Schüttler, C., Sedlmayr, B., Twrdik, A., Kiel, A., & Majeed, R. W. (2022). The architecture of a feasibility query portal for distributed COVID-19 Fast Healthcare Interoperability Resources (FHIR) patient data repositories: Design and implementation study. JMIR Medical Informatics, 10(5), e36709.
23. Rosenau, L., Majeed, R. W., Ingenerf, J., Kiel, A., Kroll, B., Köhler, T., Prokosch, H.-U., Szimtenings, L., & Gruendner, J. (2022). Generation of a Fast Healthcare Interoperability Resources (FHIR)-based ontology for federated feasibility queries in the context of COVID-19: Feasibility study. JMIR Medical Informatics, 10(4), e35789.
24. Kolla, S. H. (2022). Strategic Information Integration Models for Cross-Functional Service Optimization in Large-Scale Enterprises. International Journal of Emerging Trends in Engineering and Management Research, 7(3), 11811.
25. Davis, B. D., & Swenson, A. (2022). How Carequality, The Sequoia Project, and eHealth Exchange support the interoperable exchange of health data in the USA. Journal of Digital Imaging, 35, 812–816.
26. Kebede, H., Shivers, J., Gebremeskel, T., et al. (2022). eHealth architecture-based health data exchange: Ethiopia DHIS2 and SmartCare. Journal of Health Informatics in Africa, 8(1), 9–18.
27. Mandl, K. D., et al. (2022). The patient role in a federal national-scale health information exchange. Journal of Medical Internet Research, 24(11), e41750.
28. Bennett, A. M., Ulrich, H., van Damme, P., et al. (2023). MIMIC-IV on FHIR: Converting a decade of in-patient data into an exchangeable, interoperable format. Journal of the American Medical Informatics Association, 30(4), 718–725.
29. Nan, J., & Xu, L.-Q. (2023). Designing interoperable health care services based on Fast Healthcare Interoperability Resources: Literature review. JMIR Medical Informatics, 11, e44842.
30. Inala, R. (2023). Revolutionizing Customer Master Data in Insurance Technology Platforms: An AI and MDM Architecture Perspective. International Journal of Finance (IJFIN)-ABDC Journal Quality List, 36(6), 579-606.
31. Williams, E., Kienast, M., Medawar, E., Reinelt, J., Merola, A., Klopfenstein, S. A. I., Flint, A. R., Heeren, P., Poncette, A.-S., Balzer, F., Beimes, J., von Bünau, P., Chromik, J., Arnrich, B., Scherf, N., & Niehaus, S. (2023). A standardized clinical data harmonization pipeline for scalable AI application deployment (FHIR-DHP): Validation and usability study. JMIR Medical Informatics, 11, e43847.
32. Pedrera-Jiménez, M., García-Barrio, N., Frid, S., Moner, D., Boscá-Tomás, D., Lozano-Rubí, R., Kalra, D., Beale, T., Muñoz-Carrero, A., & Serrano-Balazote, P. (2023). Can OpenEHR, ISO 13606, and HL7 FHIR work together? An agnostic approach for the selection and application of electronic health record standards to the next-generation health data spaces. Journal of Medical Internet Research, 25, e48702.
33. Sreejith, R., & Senthil, S. (2023). Smart contract authentication assisted GraphMap-based HL7 FHIR architecture for interoperable e-healthcare system. Heliyon, 9(4), e15180.
34. Wiedekopf, J., Drenkhahn, C., & Ingenerf, J. (2023). Performance benchmarking of FHIR terminology operations in ETL jobs. Studies in Health Technology and Informatics, 302, 136–140.
35. a, S. K., & Reddy, V. A. R. (2023). Deep Learning Architectures For Multimodal Medical Data
36. Shah, R. R., & Bailey, J. P. (2023). Asymmetric interoperability as a strategy among provider group health information exchange: Directional analysis. Journal of Medical Internet Research, 25, e43127.
37. Holmgren, A. J., Esdar, M., Hüsers, J., & Coutinho-Almeida, J. (2023). Health information exchange: Understanding the policy landscape and future of data interoperability. Yearbook of Medical Informatics, 32(1), 184–194.
38. Ghosh, S., et al. (2023). Interoperability of clinical data through FHIR: A review. Procedia Computer Science, 220, 856–861.
39. Trivedi, R., et al. (2023). Establishing three layer architecture to improve interoperability in Medicare using smart and strategic API led integration. SoftwareX, 22, 101376.